The exact pathomechanism of MIS-C is not known, but immunological dysregulation leading to cytokine storm plays a central role. In response to the emergence of MIS-C, the European Academy of Allergy and Clinical Immunology EAACI established a task force TF within the Immunology Section. With the use of an online Delphi process, TF formulated clinical statements regarding immunological background of MIS-C, diagnosis, treatment, follow-up, and the role of COVID-19 vaccinations. MIS-C case definition is broad, and diagnosis is made based on clinical presentation. The immunological mechanism leading to MIS-C is unclear and depends on activating multiple pathways leading to hyperinflammation. The exact pathomechanism of MIS-C is not known, but immunological dysregulation leading to cytokine storm plays a central role. In response to the emergence of MIS-C, the European Academy of Allergy and Clinical Immunology EAACI established a task force TF within the Immunology Section With the use of an online process, TF formulated clinical statements regarding immunological background of MIS-C, diagnosis, treatment, follow-up, and the role of COVID-19 vaccinations. MIS-C case definition is broad, and diagnosis is made based on clinical presentation. The immunological mechanism leading to MIS-C is unclear and depends on activating multiple pathways leading to hyperinflammation

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Talaromycosis is a systemic disease caused by Talaromyces marneffei. To capture the characteristics of talaromycosis patients with inborn errors of immunity IEI prompts us to develop a systematic review. A systematic literature review was performed by searching PubMed, Cochrane Central Register of Controlled Trials, Web of Science, EMBASE, and Scopus. Data from patients with genetic diagnosis of IEI with talaromycosis, IEI genotypes, immunology, and clinical characteristics were collected. We downloaded GSE108109 from the Gene Expression Omnibus GEO database for bioinformatic analyses. Genome-wide expression analysis GSEA and functional enrichment analysis of differentially expressed genes DEGs were performed. Single sample gene set enrichment analysis ssGSEA was applied to assess the level of immune infiltration patterns of diseases. Protein-Protein Interaction PPI network was constructed to identify hub genes. Hub genes were intersected with immune-related genes downloaded from the Immunology Database and Analysis Portal (ImmPort) to obtain key genes. In addition, the expression levels of key genes were validated in the Kidney Interactive Transcriptomics webpage and Nephroseq database. Receiver operating characteristic (ROC) analysis and principal component analysis PCA was performed to explore the value of key genes for MCD diagnosis.