Microbial-Induced Conversion of Ingested Choline to Trimethylamine
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Eating disorders are characterized by abnormal, unhealthy eating habits and disordered body image. In severe cases, it can cause serious health consequences, including cardiac problems, osteoporosis, infertility, or missing menstrual periods. It is well known that disordered eating behaviours or eating disorders are more common among elite and competitive athletes compared to the normal population, especially in disciplines that emphasize thinness, low weight, or lean aesthetics. Although male athletes can be affected by eating disorders, females represent about 90% of those who need medical car reported a much greater problem with eating in the results of their study. The authors demonstrated that the risk of developing eating disorders affected 76.9%, 72.2%, and 66.7% of young girls training in ballet, beach volleyball, and volleyball, respectively. The results are divergent, partly due to different research tools used, and partly due to the sports disciplines represented by sportswomen. In certain disciplines, the way of eating and peer pressure are factors influencing eating behaviours and body weight of sportswomen. In patients with pre-existing cardiovascular disease, the microbial-induced conversion of ingested choline to trimethylamine affects the health of the cardiovascular system. Elevated blood levels of N-trimethylamine oxide have been directly linked to adverse outcomes in patients with such conditions, such as coronary artery disease and heart failure. Over time, the microbiome begins to produce toxic molecules, including N-trimethylamine oxide, which enter the bloodstream, causing inflammation. The age-related microbial imbalance of the gut microbiome contributes to the development of oxidative stress and inflammation that underlie arterial dysfunction. Such findings, therefore, support that good gut microbiota help prevent cardiovascular disease. A stroke is an acute cerebrovascular disease that primarily manifests as a blockage of blood vessels in the brain. Ischemic or hemorrhagic strokes are the most common kinds of stroke, and males over the age of 40 are more likely to suffer from them. The two clinical treatments for stroke that are most commonly used are thrombolytic therapy and drug therapy. Due to the substantial risk of problems that are associated with both of these treatments, there is no improvement in the prognosis for stroke. Nutritional support therapy is an important intervention that should be used in the treatment of acute severe stroke. To account for the treatment and the provision of appropriate nutrition for recovery in later stages, most studies have utilized early EN maintenance therapy.