Kidneys play a pivotal role in maintaining the acid-base balance of body along with lungs, and they do so by reabsorbing filtered bicarbonate and removing excess hydrogen ions. Renal disorders due to the removal of HCO3 or acid handling in the presence of relatively preserved GFR are collectively referred to as renal tubular acidosis. It is a non-anion gap hyperchloremic metabolic acidosis. This activity reviews the causes, pathophysiology, and presentation of renal tubular acidosis and highlights the role of the interprofessional team in its management.Autoimmune diseases are the commonest cause in adults: Systemic lupus erythematosus (SLE), Sjogren syndrome, rheumatoid arthritis, systemic sclerosis, thyroiditis, hepatitis, primary biliary cirrhosisInherited, AD or AR: Genetic primary causes of distal RTA include mutations of genes that encode the chloride-bicarbonate exchanger (AE1) or subunits of the H-ATPase pump respectively.

• ype 1 RTA, or distal RTA, occurs when there is a problem at the end or distal part of the tubules.
• Type 2 RTA, or proximal RTA, occurs when there is a problem in the beginning or proximal part of the tubules.